Farmakope herbal indonesia edisi 24/1/2024 ![]() Keywords : Boesenbergia pandurata, doxorubicin, MCF-7/HER2, migrationĪmalina, N.D., Nurhayati, I.P. The mechanism underlying the migratory inhibition effect needs to be explored further. Thus, BPEE is potential to be developed as an antimetastatic agent. The combination of 5 μg/mL BPPE and 10 nM doxorubicin inhibited the cells migration but not affect to the cells viability. Lamellipodia and wound healing assay analysis showed that 5 μg/mL BPPE and its combination with 10 nM doxorubicin inhibited cells migration after 48 hours observation, while gelatin zymography analysis showed that this combination did not affect the expression of Matrix Metalloproteinase (MMP)2 and MMP9, but single treatment of 5 μg/mL BPEE caused lower expression of both MMPs. Under MTT assay, BPEE decreased the cells viability with IC50 value of 23☓.9 μg/mL. The BPEE was prepared by 96% ethanol maceration. The aim of this study is to observe the inhibitory effect of Boesenbergia pandurata ethanolic extract (BPEE) in combination with doxorubicin on migration of MCF-7/HER2 cells. ![]() ![]() Boesenbergia pandurata is well known as medicinal plant possessing anticancer potential due to the cytototoxic and antimetastatic characteristic of its active compound. The development of breast cancer at an advanced stage is signed with metastatic phenomenon, triggering the high mortality, mainly for Human Epidermal Growth Factor Receptor (HER)2 positive cancers. ![]()
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